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Setola E, Monti L, Galluccio E, Palloshi A, Fragasso G, Paroni R, Magni F, Sandoli E, Lucotti P, Costa S, Fermo I, Galli-Kienle M, Origgi A, Margonato A, Piatti P

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Important Epithalon Research Limitations The literature is concentrated within a small research network and relies heavily on preclinical models

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Keywords: chondrocyte, senescence, autologous chondrocyte implantation, senolytic, FOXO4-DRI Introduction Autologous chondrocyte implantation (ACI) is a biomedical treatment that repairs cartilage injury in the knee joint, which has been shown to reduce pain and facilitate mobility recovery (Kreuz et al., 2019)

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