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Administer the dose only if the vial was at room temperature (2025C) for fewer than 12 hours and you're within the first two weeks of the 28-day beyond-use window

Taken together with the findings that utilization of esketamine as an antidepressant increases LAC levels [59], the fact that the decrease in LAC levels in subjects with MDD is independent of psychotropic drug treatment raises the possibility that increasing LAC levels may be needed to induce antidepressant effects

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This record matters because patterns of early or late injections can affect how your body responds to dose escalation or medication switches