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However, the efficacy in overall improvements of symptoms of pregabalin may not be as comparable to that of SNRIs and may induce more somatic symptoms seen in FM [94]

A previous study indicated that capsiate enhances GPX4 expression and suppresses ferroptosis through the activation of transient receptor potential cation channel subfamily V member 1, along with the attenuation of intestinal I/R injury [88]

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The better effect of LCLN than LC was evidenced by the findings of earlier studies 92,100 , likely due to physical attributes (including shape, size, and zeta potential), alongside enhancements in encapsulation efficiency, drug content, drug loading capacity, drug release, and in vitro release of the formulated LC-SLNs, all of which were optimized in the niosomal form 19