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Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity

Cancer 20 , 333353 (1967)

Only two studies have demonstrated ferroptosis inhibition in preclinical models of NDDs, with quercetin showing efficacy in PD and eriodictyol in AD, while no studies have been conducted in HD (Lin et al., 2022

Furthermore, the neuroprotective effects of RES are associated with global transcriptome remodeling, involving the activation and suppression of specific signaling pathways, as well as its role as a free radical scavenger