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This fixed-ratio combination leverages complementary mechanisms of action to produce superior metabolic effects compared to either agent alone [7] : The CagriSema combination demonstrates that dual targeting of amylin and GLP-1 receptors produces additive or synergistic effects, representing a promising avenue for advanced metabolic research [7]

Furthermore, caveolin 1 knockout augmented steatosis both in vitro and in vivo by enhancing the expression of genes involved in DNL [30], contradicting earlier studies, and suggesting a protective effect of caveolin 1 in NAFLD [30]

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Ferrannini E, Ramos SJ, Salsali A, Tang W, List JF