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A slight but significant increase of coumarin-6 uptake by ischemic brains of mice was observed with GSH coated PLGA-PEG nanoparticles when compared with non-GSH coated PLGA-PEG nanoparticles [51]

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Among these, topical metronidazole and tetracycline and systemic tetracycline and isotretinoin are the most important options