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While Habener had patented this discovery, it wasnt licensed to a company at the time

In colon epithelia, clostridium perfringens enterotoxin causes focal leaks by targeting claudins which are apically accessible due to tight junction derangement

Tumor angiogenesis produces chaotic, leaky vessels that never fully mature

With lower estrogen, your body naturally produces more free radicals (unstable molecules that can damage cells) and your mitochondria are a prime target