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144 The Warburg effect indicates that lower intratumoral glucose levels can impede tumor growth, which can be achieved through pharmacological intervention and dietary changes such as a KD

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Within the H-site, the substrate analogue ( 12 ) interacts through hydrogen bonds to N108 and the backbone of V12, a interaction with F112, water bridges to R16 and Y175, and hydrophobic interactions with V12 and V115 (Fig