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Yet other studies have pointed toward DPP-4 acting as a hepatokine, linking the liver and adipose tissue with the development of insulin resistance, and glucose intolerance

Homogenates were centrifuged at 800 g for 10 min at 4 C, and the supernatant was sonicated on ice for 20 s before protein quantification (BCA protein assay, Pierce, Rockford, IL, USA)

In the SURMOUNT-1 clinical trial of adults without diabetes, participants lost an average of 15-21% of body weight over 72 weeks when combined with lifestyle modifications, with somewhat lower weight loss observed in people with type 2 diabetes

doi:10.1038/362814a0