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A CD44-targeted TLR7/8 nanovaccine for synergistic photothermal immunotherapy

Using quantitative proteomics of chromatin-associated spliceosomes, we identify a previously uncharacterized intermediate complex B OTS964 , arrested by CDK11 inhibitor OTS964, that incorporates the nineteen-related (NTR) but not nineteen (NTC) complex

Mechanistically, we show that, upon GSH depletion, the liver tissue induces the expression of target genes associated with the antioxidant transcription factor NRF2