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Common gastrointestinal adverse effects reported in clinical trials include: Nausea (approximately 44% of patients) Diarrhoea (approximately 30%) Vomiting (approximately 24%) Constipation (approximately 24%) Abdominal pain (approximately 20%) Dyspepsia (approximately 9%) These effects are typically most pronounced during dose escalation and tend to diminish over time as the body adapts

Its weight-loss version, Wegovy, changed the field when it was approved as a once-weekly injection in June 2021

Despite the potential of certain compounds, such as DCA and elamipretide, to augment these metabolic pathways, their clinical application remains constrained by adverse toxicological profiles and insufficient efficacy in patient populations 10,12

Status: Currently in phase-2 clinical trials