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The fitting results showed that the maximum concentration of glucose in GLP-1R KO mice was 11.56 1.6 mM, whereas that in WT mice was 11.57 1.4 mM

Other GLP-1 medications may have varying durations, but the principle remains the same: the longer the half-life, the longer the hormone stays active in your system

The authors cited evidence linking abrupt glucose reduction during intensive diabetes treatment to early worsening of DR, a pattern that may parallel findings seen with GLP-1 initiation