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These include having a body mass index (BMI) of at least 27 and experiencing weight-related health issues such as type 2 diabetes, high cholesterol , or high blood pressure

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If neurological symptoms are present, injections may continue on alternate days until no further improvement, followed by maintenance injections every 2-3 months for life Oral B12 supplementation : High-dose oral cyanocobalamin (10002000 micrograms daily) may be effective for dietary deficiency without malabsorption

In some specific research protocols, alternatives are used: Sterile water for injection (WFI) , when the entire contents of the vial are used at once and a preservative is not needed Physiological saline (0.9% NaCl) , in some applications requiring an isotonic environment Acidic solvents (e.g