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A large number of clinical studies have shown that this loss of appetite caused by treatment with semaglutide or tirzepatide is associated with a significant decrease in body weight in people who suffer from obesity
The Reality of Weight Regain If Tirzepatide is discontinued abruptly without a maintenance strategy, many patients experience a return of hunger signals (the food noise) and a slowing of the metabolic rate, which can lead to weight regain
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Clinical studies show tirzepatide provides superior A1C reduction (up to 2.4% decrease) and weight loss compared to semaglutide, but requires careful monitoring for hypoglycemia, especially in patients on insulin or sulfonylureas
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