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That is more than the company spent on research and development over the past three decades combined, undermining arguments by Big Pharma that high prices are needed to convince companies to invest in R&D

TMAO has also been found to promote plaque formation by stabilizing and adjusting the assembly of the amyloid- (A) peptide (Yang et al., 1999) and fibrillation of tau protein by inducing the secondary structure formation at the C terminus in vitro (Scaramozzino et al., 2006)

In high concentrations, this may result in cellular toxicity [3-6] and has the potential to be neurotoxic [7]