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Both compounds use fatty acid modifications to extend half-life and enable weekly dosing

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Camellia sinensis ), quercetin ( Allium cepa, Malus domestica ), baicalin ( Scutellaria baicalensis ), and berberine ( Berberis spp .) have been reported to suppress S aggregation, improve mitochondrial function, and preserve dopaminergic neurons by modulating sirtuin and PI3K/Akt signaling pathways ( This article delineates the mechanistic interplay in PD between S pathology, sirtuin dysregulation, and impaired insulin signaling, illustrating how systemic metabolic dysfunction may contribute to the progression of neurodegeneration