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3 Mechanisms of sulforaphane-based neuroprotection 3.1 Sulforaphane and oxidative stress regulation Reactive oxygen species (ROS), such as superoxide anions and hydrogen peroxide, are byproducts of cellular metabolism and function within organelles such as mitochondria, endoplasmic reticulum, and peroxisomes ( As described above, sulforaphane modifies cysteine residues within the KEAP1 ubiquitin ligase, albeit distinct cysteine residues from those that become oxidized by ROS (Figure 2)

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I.ReitmayerC.ArndtC.WoberJ.KretzschmarG.ZierauO.et al (2012)

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