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149 eNAMPT induces IL6 secretion, which activates the autocrine/paracrine loop mediated by STAT3, increasing the resistance of macrophages to the cell death induced by endoplasmic reticulum stress

These are generally temporary and part of the recovery process

Cardiovascular outcomes and other key takeaways Overall, the authors found that all six OMMs were associated with significant improvements in weight loss compared to a placebo