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Using pKa values and the Principle of Acid-Base Mediocrity To Predict Acid-Base Reactions With these two mental tools the higher the pK a , the weaker the acid, and the Principle Of Acid Base Mediocrity, we are all set to use pK a values to predict the directions of acid-base reactions

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Thiazide & Thiazide-like Diuretics Site: Distal Convoluted Tubule (DCT) Thiazides: Hydrochlorothiazide Chlorothiazide Thiazide-like: Chlorthalidone Indapamide Metolazone Uses: Hypertension, mild edema, nephrogenic diabetes insipidus 5

The real question becomes: Are we ready to revise the guidelines and integrate these drugs into safe, personalized pathways for T1D with obesity