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Tirzepatide has a half-life of approximately 5 days, with elimination occurring over several weeks

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FDA staff's own briefing document, posted publicly ahead of the meeting as part of the docket, proposes that TB-500 (free base) and TB-500 acetate not be added to the list, citing incomplete physicochemical characterization, a lack of evidence of effectiveness for wound healing (including an in-vitro fibroblast study in which TB-500 reportedly did not induce wound healing), and insufficient nonclinical and clinical safety data

DOI:10.1111/j.1467-2494.2005.00235.x [ Links ] 22