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180 Deep brain stimulation involves the use of electrodes implanted in the brain to deliver electrical impulses directly to specific brain regions, and is under investigation as a treatment option for individuals with obsessive-compulsive disorder and post-traumatic stress disorder

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One example of this is tetrahydrobiopterin (BH4), an essential enzyme cofactor that is required to produce tyrosine and dopamine, that has been discussed as a potential treatment target (Sperner-Unterweger et al., 2014)

Ethics statement The animal study was approved by the experimental protocol was approved by the Institutional Animal Care and Use Committee of Jining Medical University (Approval No