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As previously mentioned, pharmaceutical companies are prohibited from marketing their drugs for off-label uses, and any claims about the drugs effectiveness for weight loss outside of FDA-approved indications should be viewed with skepticism

Opposite to the effects of GRK inhibition, a PKC inhibitor blunted short-term analgesic tolerance to morphine but not DAMGO (Hull et al., 2010), and in locus coeruleus neurones, cellular tolerance to DAMGO was not reversed by PKC inhibitors (Bailey et al., 2009a)

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It is non-addictive and preserves the complete physiology of the sleep-wake cycle