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Wnt signaling is a master regulator of stem cell maintenance, tissue regeneration, and hair follicle cycling

275,276 SGLT-2Is reduce MACE (primarily by reducing cardiovascular death), 277 hospitalizations due to heart failure, 278 and CKD progression 278 (including significant reductions in albuminuria and delayed eGFR decline) in various populations, irrespective of baseline glycemic status

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