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GPX4: Glutathione peroxidase 4 ROS: Reactive oxygen species PTMs: Post-translational modifications GPI: Glycosyl phosphatidylinositol PRDX3: Peroxiredoxin 3 FSP1: Ferroptosis suppressor protein 1 DHODH: Dihydroorotate dehydrogenase GCH1: GTP cyclohydrolase 1 BH4: Tetrahydrobiopterin GSH: Glutathione SLC3A2: Solute carrier family 3 member 2 SLC7A11: Solute carrier family 7 member 11 PLOOH: Phospholipid hydroperoxides PTL: Parthenolide TNBC: Triple-negative breast cancer CKB: Creatine kinase B mTORC2: Mtor complex 2 ACSL1: Acyl-coa Synthetase Long-Chain Family Member 1 CRISPRa: CRISPR-Cas9 gene screening and genome-wide dcas9-based activation screening IMM: Inner membrane TMZ: Temozolomide LOXL3: Lysyl oxidase-like 3 AK2: Adenylate kinase 2 MBOAT1/2: Membrane-bound O-acyltransferase domain containing 1 and 2 PE: Phosphatidylethanolamine PUFA: Polyunsaturated fatty acid AA: Arachidonic acid AdA: Adrenic acid ALOX: Arachidonate lipoxygenases PEBP1: PE-binding protein 1 POR: P450 oxidoreductase MUFAs: Monounsaturated fatty acids ACSL3: Acyl-coa synthetase long-chain family member 3 DMT1: Divalent metal transporter 1 LIP: Labile iron pool NCOA4: Nuclear receptor coactivator 4 EAAT3: Excitatory amino acid transporter 3 GCL: Glutamate-cysteine ligase MAT2A: Methionine adenosyltransferase 2A DUBs: Deubiquitinases SMURF2: SMAD-specific E3 ubiquitin ligase 2 GSTP1: Glutathione S-transferase P1 DOX: Doxorubicin NSCLC: Non-small cell lung cancer PD: Parkinson's disease I/R: Ischemia-reperfusion USP7: Ubiquitin-specific protease 7 hnRNPA1: Heterogeneous nuclear ribonucleoprotein A1 SCD: Stearoyl-coa desaturase USP8: Ubiquitin-specific protease 8 BAP1: BRCA1-associated protein 1 HCC: Hepatocellular carcinoma CCA: Cholangiocarcinoma SHARPIN: Shank-associated RH domain interacting protein MDA: Malondialdehyde NO: Nitric oxide CRC: Colorectal cancer IVDD: Intervertebral disc degeneration USP11: Ubiquitin-specific protease 11 SIRT3: Sirtuin 3 PK: Protein kinases PPase: Protein phosphatases AMPK: AMP-activated protein kinase ACC: Acetyl-coa carboxylase PRKCQ: Protein kinase C theta HPCAL1: Hippocampal calcium-binding protein-like 1 CDH2: Cadherin 2 GLP-1: Glucagon-like peptide-1 MTOR: Mechanistic target of rapamycin kinase DHO: Dihydroorotate PrA: Protosappanin A IGF1R: Insulin-like growth factor 1 receptor OXA: Oxaliplatin Nrf2: Nuclear factor erythroid 2-related factor 2 SFN: Sulforaphane CREBBP/CBP: CREB-binding protein SIRT1: Sirtuin 1 CTH/CSE: Cystathionine -lyase GINS4: GINS complex subunit 4 LUAD: Lung adenocarcinoma CaOx: Calcium oxalate NAMPT: Nicotinamide phosphoribosyltransferase HDAC: Histone deacetylase HAT: Histone acetyltransferase AKI: Acute kidney injury NAT10: N-acetyltransferase 10 HMGA2: High mobility group AT-hook 2 CAP: Cold atmospheric plasma IL-1: Interleukin-1 HMT: Histone methyltransferases HKMTs: Histone lysine methyltransferases PRMTs: Protein arginine methyltransferases KMT2B: Lysine-specific methyltransferase 2B PRMT7: Protein arginine methyltransferase 7 PRMT4: Protein arginine methyltransferase 4 LC-3: Light chain protein-3 HAECs: Human airway epithelial cells LC-3I: Light chain protein-3I RPE: Retinal pigment epithelial LCN2: Lipocalin 2 GBM: Glioblastoma multiforme MYR: N-myristoylation NMT: N-myristoyltransferase ZDHHC: Zinc finger, aspartate-histidine-histidine-cysteine CPT1A: Carnitine palmitoyltransferase 1A PAT: Protein acyltransferase IFN: Interferon-gamma IFNGRs: Interferon-gamma receptor CS: Cigarette smoke RPE: Retinal pigment epithelial ER: Estrogen receptor SREBP1: Sterol regulatory element-binding protein GSNO: S-nitrosoglutathione RNS: Reactive nitrogen species ACLY: ATP citrate lyase HDACi: Histone deacetylase inhibitors TEC: Tectorigenin MAP4K4: Mitogen-activated protein kinase kinase kinase kinase 4 SNO-Drp1: S-nitrosylation of Drp1 EPHX1: Microsomal epoxide hydrolase 1 MALT1: Mucosa-associated lymphoid tissue lymphoma translocation protein 1 PCK2: Phosphoenolpyruvate carboxykinase 2 We thank the Public Service Platform of South China Sea for R&D Marine Biomedicine Resources for support

Aging appears to follow a predictable biological pattern at both the cellular and systemic levels

Physiol Res 69:835845

J Rheumatol