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Yamamura, K

Despite the guideline-recommended use of both SGLT2i and GLP-1RA therapy, there is a paucity of real-world evidence on the long-term effects of combining SGLT2is with newer generation GLP-1RAs (including once-weekly GLP-1RAs, once-daily oral semaglutide, and dual GLP-1/glucose-dependent insulinotropic polypeptide [GIP] agonists) on metabolic outcomes and other cardiorenal outcomes [22]

Despite not being a primary aim of the study, by collecting participant characteristics we saw clinically significant improvements in physical health (weight and HbA1c), of similar magnitude to that seen in trials of GLP-1 receptor agonists in obesity [35] and T2D and overweight [36, 37]

B.ShimJ.-H.ZouW.SitaraD.SchweitzerM.HuD.et al (2010)