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According to the company and consistent with published pre-clinical literature, it has been studied in animal models for pre-clinical signals related to the gastrointestinal environment, inflammatory responses in the GI tract, and tissue-related processes in tendon and joint contexts - all per pre-clinical animal data, not established human clinical outcomes

A meta-analysis of randomized controlled trials by Fujiya et al

Compared to metformin, thiazolidinediones act more effectively on peripheral tissues (adipose tissue, muscle) than on the liver due to the specific distribution of their target receptors [55]

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