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If microdosing is about small, steady biological nudges, then full doses, or macrodosing, is about reaching the full therapeutic dose needed to create a more pronounced metabolic effect

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Context for confounding and differential diagnosis: SGLT2 inhibitors are known to increase genital mycotic infection risk, including vulvovaginal candidiasis, and real-world studies demonstrate clinically significant vaginitis incidence in usersmaking SGLT2 exposure a critical confounder when patients attribute yeast infections to semaglutide

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