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They are generally safer than synthetic drugs

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Overall, polyphenols exhibit antioxidant properties through various pathways, including free radical scavenging and the augmentation of endogenous antioxidant enzyme activity (174, 175)

A., Davis R., et al., Exendin4 Reduces Fasting and Postprandial Glucose and Decreases Energy Intake in Healthy Volunteers, American Journal of PhysiologyEndocrinology And Metabolism 281 (2001): E155E161, 10.1152/ajpendo.2001.281.1.e155