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demonstrated that oral KPV at 100 uM in drinking water reduced DSS-induced colitis severity by roughly 50% (measured by myeloperoxidase activity) in mice

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There are also several non-catalytic antioxidant proteins such as the glutaredoxins, the thioredoxins (Trx), and the metallothioneins (MT)

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These findings suggest that exploiting CHAC1 is potentially safe for TP53-mutant tumors

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