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Overcoming biological barriers is an additional and also important challenge: the mucus layer is the first line of barrier due to its negative charge and viscosity which can hinder the penetration of peptide drugs
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Incretin therapieshighlighting common features and differences in the modes of action of GLP-1 receptor agonists and DPP-4 inhibitors
Growth factors such as (e.g., VEGF, platelet-derived growth factor [PDGF] bind to a receptor tyrosine kinase (RTK) on the cell membrane, causing autophosphorylation of the receptor, thus creating docking sites for intracellular signaling proteins
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