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The disorder is caused by an autosomal recessive defect in ADSL (OMIM 608222), which encodes the enzyme ADSL involved in the de novo synthesis of purines

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Despite randomized clinical trials demonstrating that amlodipine did not exhibit favorable clinical effects for the treatment of chronic heart failure (45, 46), amlodipine therapy could be used as adjunctive therapy in cases of iron overload, as seen in our patient's case and recent randomized clinical trials of amlodipine in patients with iron overload ( 5