Introduction Rheumatoid arthritis (RA) is a common chronic inflammatory disease and systemic autoimmune disease, mainly involving the synovial joints, and is characterized by destroyed immune regulation of the joint synovial membrane, systemic inflammation and the existence of autoantibodies, which finally lead to severe damage and destruction of cartilage and bone ( Polyphenols Resveratrol Resveratrol (RES) (3,5,4-trihydroxystilbene) is a natural antioxidant that exists in a variety of plants, such as Cassia obtusifolia, Veratrum nigrum, Polygonum cuspidatum, grapes, soybeans and nuts, and has a variety of pharmacological effects, as well as therapeutic effects on a variety of autoimmune diseases, including RA ( The research by Buhrmann C et al
Resveratrol, an antioxidant, which is believed to increase sirtuin 1 expression, was able to delay onset of symptoms, prevent motor neuron loss and extend survival when treatment was initiated at early stages of the disease in hSOD1 G93A mice (Mancuso et al., 2014)
compositions may, optionally, additionally comprise one or more pharmaceutically acceptable excipients, diluents, and/or carriers, one or more vitamins, essential amino acids, or minerals, one or more antioxidants, one or more additional glutathione precursors, and/or one or more nutritional diet supplement components, for example
10.1051/ANPHYS/193210170283 473 PerutzM
