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Fleur represents a novel therapeutic approach to Type 2 Diabetes Mellitus (T2DM) and obesity management through engineered probiotic bacteria that express and secrete wild-type glucagon-like peptide-1 (GLP-1) directly within the human gastrointestinal tract

BMI is a useful starting point, but it does not tell the entire story

BMC Med (2018) 16: 18.) Several melatonin receptor agonists have been synthesized, some of them have higher affinity for the receptor than endogenous melatonin

Acknowledgements The authors would like to thank Thomas Rohban, MD, and Magalie El Hajj, PharmD, from Partner 4 Health (Paris, France) for providing medical writing support in accordance with Good Publication Practice (GPP3) guidelines