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Aetna is more likely to cover Mounjaro for people with a diagnosis of type 2 diabetes who have had an inadequate response or intolerance to metformin, who need combination therapy, and have an A1C of 7.5 percent or greater

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Investigators have also noted that the pronounced appetite-stimulating effect of MK-677 an on-target consequence of ghrelin receptor agonism in hypothalamic appetite circuits complicates body composition endpoints in metabolic studies, as caloric intake must be carefully controlled to isolate GH-axis-mediated changes from orexigenic-driven weight gain