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Randomised controlled trials are needed to confirm these disease-modifying effects

Although preliminary findings indicate that GLP-1Ra causes modest BMD reduction and enhances bone remodeling, favoring resorption similar to the effects of calorie restriction, further research is needed

While no direct contraindication exists for concurrent use, the absence of controlled trials means safety and efficacy remain inadequately characterized

[79] When used together with alpha-blockers, no benefit was reported in short-term trials, but in a longer-term study (34 years) there was a greater reduction in BPH progression to acute urinary retention and surgery than with either agent alone, especially in people with more severe symptoms and larger prostates