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Because mitochondria control the ratios of NADH/NAD+, NADPH/NADP+, and GSH/GSSG, alterations in redox homeostasis have been proposed as a potential cause of ageing (Leeuwenburgh et al., 2011)
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Collectively, these data may suggest that ROS outbursts induced by CP treatment may represent a critical mediator in regulating necroptosis induction
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