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N Engl J Med 2010;362:2077-91

Furthermore, in rats fed a fructose-rich diet, Spirulina supplementation increased the abundance of Prevotellaceae and Lactobacillaceae and reduced the Firmicutes-to-Bacteroidetes ratio, thereby restoring gut microbial balance

The review also notes a temporary worsening of diabetes-related retinopathy during rapid glycemic improvement, an increased aspiration risk from delayed gastric emptying, and the need to protect against nutritional deficiencies and loss of muscle or bone mass during rapid weight loss

Reutilization and exposure of those containers to temperatures greater than 70 C results in BPA leakage to food and beverage which ultimately leads to the dietary ingestion of BPA to humans (88)