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AOD-9604 vs Alternatives Compared to GHRH analogs such as tesamorelin or CJC-1295, which act upstream by stimulating pituitary GH release and downstream IGF-1, AOD-9604 operates further down the pathway with a narrower receptor footprint

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However, overall mortality was not affected by extent of tumor resection or the addition of radiation therapy as an adjuvant, highlighting the need for continued efforts toward the development of effective treatment options to improve survival in patients with melanotic schwannomas