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For example, certain gut bacteria produce neuroactive metabolites and help modulate inflammatory pathways, crucial in depressive disorders [226,227]

In addition, low levels of stomach acid and IF in older populations can make getting enough through diet tricky, which is why supplementation is typically recommended

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Summary of the findings The current article evaluated 13 studies, of which eight were randomized clinical trials comparing different administration routes of vitamin B12 in patients with vitamin B12 deficiency