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However, a consideration was raised by a commentary on this paper (99)

R., Greaves, D

Megson, Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits

In this regard, in the pancreatic -cell, elevation of both cAMP and cytosolic Ca 2+ and -arrestin signalling downstream of GLP-1R activation are critical events in promoting glucose-dependent insulin secretion