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Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling

Metabolic imbalances, especially in lipid and glucose metabolism, are often accompanied by increased ROS, leading to oxidative stress that further damages the vascular endothelium, inhibits NO production, and impairs vascular regulation [262, 263]

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This suggests multiple overlapping fat-loss pathways, making it a resilient addition to any protocol