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Transcriptomic profiling identified more than 5,400 differentially expressed genes in the liver and over 8,000 in adipose tissue, indicating extensive remodeling of inflammatory and metabolic pathways

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Spatial transcriptomics combined with single-cell RNA sequencing identified high expression levels of ferroptosis-related genes, including TFRC, NCO4, and SLC3A2, in granulosa cells of patients with ovarian senescence, while GPX4 expression was notably low (Lin et al., 2023)