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The risk may increase with rapid weight loss - more than 3.3 pounds per week - as this can lead to gallstones that might trigger pancreatitis

Serious Adverse Events Serious adverse events are uncommon but include acute pancreatitis (incidence similar to other GLP-1 agonists, approximately 0.2%), gallbladder disorders (cholecystitis, cholelithiasis) occurring more frequently than placebo likely due to rapid weight loss, and rare cases of severe hypoglycemia when combined with insulin or sulfonylureas

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