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Because of its blood-sugar-lowering effects, individuals with insulin-dependent diabetes or those taking oral anti-diabetic medications must consult their healthcare provider before use, as the combination can lead to severe and dangerous hypoglycemia

[10] [11] Intramuscular B12 injections (hydroxocobalamin or cyanocobalamin) bypass the digestive system, but UK product information (SmPCs) for hydroxocobalamin injections does list gastrointestinal disturbances, including diarrhoea, as possible adverse reactions, albeit rare

The trial was supposed to report results

Qsymia is approved for people aged 12 and older with obesity or adults with overweight and a weight-related health condition