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Lessens reliance on injections in the long term through sustained lifestyle changes
In addition, the SOCS gene is activated by GH signaling and works as a short intracellular negative feedback loop which rapidly down-regulate GHR activity by internalization and receptor ubiquitinoylation resulting in lysosomal and proteasomal degradation (101)
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Reaching a tendon reliably means getting the peptide into circulation, and injection does that more dependably than oral dosing's uncertain systemic fraction
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