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A 2025 UCSF open-label pilot in Parkinsons disease, the first test of a psychedelic in a neurodegenerative disease, found that two sessions improved mood, cognition, and motor symptoms for weeks to months, with a larger randomized trial now under way

Embryo-Fetal Toxicity Inform female patients of reproductive potential that hydrocodone bitartrate and acetaminophen tablets can cause fetal harm and to inform their healthcare provider of a known or suspected pregnancy (see PRECAUTIONS, Pregnancy)

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