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Why these two together (research rationale) CJC-1295 has shown dose-dependent increases in GH (210) and IGF-1 (1.53) with an estimated half-life ~68 days and preserved GH pulsatility after administration

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However, the peripheral administration of exogenous PYY 336 or Y2R agonist, administered either in the fed state or in combination with glucose, improved glucose tolerance, and stimulated insulin secretion in mice

UK consensus and NICE resources emphasise these mechanisms and management approaches