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Interestingly, peripheral inflammation induced by TLR-4 activation by systemic LPS exacerbated kainic-acid induced seizures and elevated hippocampal reactive microglia, levels of IL-1, TNF, and IL-6, and NOX subunit expression (Ho et al., 2015)

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[36] Patient enrollment was to be completed around July 2009 [37] with final completion around July 2010, [33] but enrollment in the trial was voluntarily suspended by organizers in September 2008 after the U.S