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Reported side effects in human anecdotal use are generally mild and may include: Mild nausea, particularly with oral administration Redness, itching, or irritation at the injection site Temporary dizziness or mild headache Changes in appetite or weight A significant theoretical concern revolves around its pro-angiogenic properties

Retatrutide has reported a larger average weight-loss effect than tirzepatide (the active ingredient in Mounjaro and Zepbound) in their respective trials roughly 28% versus roughly 2122% over similar timeframes largely because retatrutide adds a glucagon receptor on top of the GIP and GLP-1 targets tirzepatide already uses

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Most patients notice a reduction in hair shedding within 46 weeks of consistent topical GHK-Cu use