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Collectively, these findings provide compelling experimental evidence that circadian disruption promotes chronic inflammation and associated immune system dysregulation 136

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Functionally, we demonstrate that inhibition of DUBs in human iPSC-derived neurons (iNeurons) recapitulates some of the ubiquitylation patterns observed in aged brains 5 , establishing a causal link between DUB inactivation and age-related proteome changes

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